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Progressive Retinal Atrophy (Bullmastiff/Mastiff Type)
Affected Genes: RHO
Inheritance: Autosomal Dominant
Variant(canFam6):
chr20:5674893: G>C
Breed: Bullmastiff
Mastiff
References:
Kijas JW, Cideciyan AV, Aleman TS, Pianta MJ, Pearce-Kelling SE, Miller BJ, Jacobson SG, Aguirre GD, Acland GM. Naturally occurring rhodopsin mutation in the dog causes retinal dysfunction and degeneration mimicking human dominant retinitis pigmentosa. Proc Natl Acad Sci USA. 2002 99(9):6328-6333.
Kijas JW, Miller BJ, Pearce-Kelling SE, Aguirre GD, Acland GM. Canine models of ocular disease: outcross breedings define a dominant disorder present in the English mastiff and bull mastiff dog breeds. J Hered. 2003 94(1):27-30.