Primary Open Angle Glaucoma (Basset Fauve de Bretagne Type)
Affected Genes: ADAMTS17
Inheritance: Autosomal Recessive
Variant(canFam6):
chr3:43499969: G>A
Breed: Basset Fauve de Bretagne
General Information: Primary Open Angle Glaucoma (POAG) is a genetic eye disorder affecting Basset Fauve de Bretagne dogs, typically developing between 4-6 years of age. The condition is characterized by increased pressure within the eye, causing the eyeball to enlarge and become painful. Symptoms include excessive blinking, tearing, redness, and if untreated, optic nerve damage leading to gradual vision loss. Dogs with POAG are also at risk for lens luxation, where the lens dislocates and exacerbates glaucoma and vision loss. Immediate treatment is crucial to manage symptoms and prevent blindness. Other symptoms may include bulging eyes and cataracts, indicating the need for prompt veterinary care.
How to Read Your Dog's Test Results for this Genetic Variant:
Two Variants Detected: Dog Likely Affected
One Variant Detected: Dog Unlikely Affected
No Variants Detected: No Effect
Gene / Testing Information: Genetic testing for POAG in Basset Fauve de Bretagne dogs focuses on the ADAMTS17 gene. POAG is inherited in an autosomal recessive manner, meaning a dog must inherit two copies of the mutated gene (one from each parent) to develop the disease. Carrier dogs, with only one copy of the mutation, typically do not show symptoms but can pass the mutation to their offspring. Breeding two carriers poses a risk of producing affected puppies, with each pup having a 25% chance of inheriting the disease and a 50% chance of being a carrier. Reliable genetic testing is essential for responsible breeding practices. To eliminate this mutation from breeding lines and prevent affected pups, it is recommended not to breed two carriers. Dogs not carrying the mutation have no increased risk of producing affected pups when bred with a clear dog.
References:
Oliver JA, Forman OP, Pettitt L, Mellersh CS. Two Independent Mutations in ADAMTS17 Are Associated with Primary Open Angle Glaucoma in the Basset Hound and Basset Fauve de Bretagne Breeds of Dog. PLoS One 2015 10(10):e0140436.