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Polydactyly (Common Variant)

Polydactyly (PD) is a genetic variation in dogs that results in the presence of extra toes, particularly in certain breeds like the Great Pyrenees and Norwegian Lundehund.

Affected Genes: LMBR1

Inheritance: Autosomal Dominant

Variant(canFam6):
chr16:20011235: C>T

General Information: Polydactyly (PD) in dogs is an inherited condition characterized by the presence of additional toes beyond the normal number. Most commonly, these extra digits are found on the front limbs, often appearing as an additional dewclaw that is higher on the leg compared to the primary toes. In breeds like the Norwegian Lundehund, these extra toes are fully functional, providing an advantage in navigating rough terrains. While generally harmless, the extra toes can sometimes catch on objects or become injured, requiring regular monitoring and care. In dogs, this condition does not typically affect mobility or quality of life unless complications arise from the extra digits.

How to Read Your Dog's Test Results for this Genetic Variant:

Two Variants Detected: Dog Likely Affected

One Variant Detected: Dog Unlikely Affected

No Variants Detected: No Effect

Gene / Testing Information: Genetic testing for Polydactyly (PD) in dogs primarily involves the analysis of the LMBR1 gene, where a variant known as "PD" is associated with the development of extra toes or hind dewclaws. This condition is inherited in a semi-dominant fashion, meaning that the presence of even one copy of the mutation can lead to the expression of additional digits. For breeds where polydactyly is not traditionally a breed standard, such as the Great Pyrenees, it is essential to identify carriers of this trait to make informed breeding decisions. Breeding strategies should consider the physical characteristics desired in offspring, as well as the potential for surgical removal of non-functional digits if they pose a risk of injury. Genetic testing can help breeders avoid propagating this trait unnecessarily, especially in working or show dogs where standard foot structure is critical.

References:
Park K, Kang J, Subedi KP, Ha JH, Park C. Canine polydactyl mutations with heterogeneous origin in the conserved intronic sequence of LMBR1. Genetics. 2008 179(4):2163-2172.