Neuronal Ceroid Lipofuscinosis 6

Neuronal Ceroid Lipofuscinosis 6 (NCL6) is an inherited lysosomal storage disorder that affects dogs, leading to the buildup of waste compounds in the nervous system due to a deficiency in a specific enzyme. This results in a range of severe neurological symptoms that typically emerge around 1.5 years of age. Affected dogs may exhibit progressive loss of vision, changes in behavior, anxiety, lack of muscle coordination, and abnormal gait. As the disease advances, these symptoms become more pronounced, often leading to the need for humane euthanasia by 2 years of age due to the debilitating effects of the disorder.