Litter size in Entlebucher Mountain dogs
Affected Genes: GDF9
Inheritance: Autosomal Recessive
Variant(canFam6):
chr11:19949857 G>A
Breed: Entlebucher Mountain dogs
General Information: Litter size in Entlebucher Mountain Dogs is influenced by genetic factors, with the GDF9 gene playing a role in regulating the number of offspring produced in a single litter. Dogs with certain variants of the GDF9 gene may experience smaller litter sizes compared to those without the mutation. This condition can affect breeders' expectations for the number of puppies per litter, with smaller litters potentially leading to fewer breeding opportunities. While the gene mutation does not cause health problems for the mother or the puppies, it may have an impact on breeding management and population planning in the breed. The effect of the mutation is typically observed over multiple litters rather than in a single breeding instance.
How to Read Your Dog's Test Results for this Genetic Variant:
Two Variants Detected: Dog Likely to Produce Smaller Litters
One Variant Detected: Dog Unlikely to Produce Smaller Litters
No Variants Detected: No Effect
Gene / Testing Information: Genetic testing of the GDF9 gene can help determine if a dog is likely to produce smaller litters. This trait is inherited in an Autosomal Recessive manner, meaning that dogs must inherit two copies of the variant gene, one from each parent, to exhibit reduced litter sizes. Dogs carrying one copy of the mutation generally do not experience smaller litters, but they can pass the gene to their offspring. When two carriers are bred, each puppy has a 25% chance of inheriting two copies of the mutation and producing smaller litters, and a 50% chance of being a carrier. Genetic testing is useful for breeding decisions, helping breeders manage expectations for litter size and maintain diversity within breeding lines.
References:
Torrecilha R.B.P. , Milanesi M., Wade C.M., Gallana M., Falbo A.K., Reichler I.M., Hug P., Jagannathan V., Trigo B.B., Paulan S.C., Bruno D.B., Garcia S.D., Scaramele N.F., Lopes F.L., Dolf G., Leeb T., Sölkner J., Garcia J.F., Pienkowska-Schelling A., Schelling C., and Utsunomiya Y.T. Association of missense variants in GDF9 with litter size in Entlebucher Mountain dogs. Anim. Genet. 51(1):78-86.