Leukocyte Adhesion Deficiency, Type III

General Information: Leukocyte Adhesion Deficiency, Type III (LAD-III) is a genetic blood disorder that affects dogs by causing abnormal platelet and white blood cell activity, which results in impaired blood clotting and immune system function. Affected dogs may exhibit symptoms such as lameness, prolonged bleeding, and recurrent chronic infections, especially of the skin and gums, often accompanied by fever. They also typically have persistently elevated white blood cell counts (leukocytosis). While dogs with LAD-III can live for several years, they are highly susceptible to life-threatening bleeding from accidental injuries or surgical procedures. It is essential for veterinarians performing surgery on affected dogs to have access to banked blood for transfusions to manage the risk of severe bleeding.

How to Read Your Dog's Test Results for this Genetic Variant:

Two Variants Detected: Dog Likely Affected

One Variant Detected: Dog Unlikely Affected

No Variants Detected: No Effect

Gene / Testing Information: Genetic testing for Leukocyte Adhesion Deficiency, Type III (LAD-III) involves screening for mutations in the FERMT3 gene to determine carrier status. LAD-III is inherited in an autosomal recessive manner, meaning that a dog must inherit two copies of the mutated gene, one from each parent, to develop the disease. Carriers, who have one copy of the mutation, do not typically show symptoms but can pass the mutation to their offspring. When two carriers are bred, each puppy has a 25% chance of being affected and a 50% chance of being a carrier. To prevent producing affected puppies and eliminate the mutation from breeding lines, it is crucial to avoid breeding two carriers. Genetic testing is essential for responsible breeding practices, ensuring that dogs not carrying the mutation do not pose a risk of producing affected puppies.