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Ectodermal Dysplasia, X-Linked (Dachshund Type)
Affected Genes: EDA
Inheritance: X-Linked Recessive
Variant(canFam6):
chrX:45335866: 1 bp deletion T
Breed: Standard Smooth Dachshund
General Information: X-linked ectodermal dysplasia in dogs is an inherited disorder causing symmetrical hairlessness, primarily on the head, lower back, chest, abdomen, and inner limbs. Affected dogs typically have missing or abnormal sweat glands and often present with missing or irregularly spaced teeth. Chronic nasal discharge and a heightened risk of respiratory and skin infections are common, with some cases severe enough to be fatal or necessitate euthanasia.
How to Read Your Dog's Test Results for this Genetic Variant:
Two Variants Detected: Dog Likely Affected
One Variant Detected: Dog Unlikely Affected
No Variants Detected: No Effect
Gene / Testing Information: Genetic testing of the EDA gene can identify carriers of X-linked ectodermal dysplasia in dogs. This disorder is inherited in an X-linked manner, meaning males need only one mutated gene from their mother to develop the disease, while females need two copies. Consequently, males are more commonly affected, though carrier females may show mild symptoms. Each male pup from a carrier mother has a 50% chance of inheriting the disorder. To prevent affected pups, breeding known carriers is not recommended.
References:
Vasiliadis D, Hewicker-Trautwein M, Klotz D, Fehr M, Ruseva S, Arndt J, Metzger J, Distl O. A de novo EDA-variant in a litter of shorthaired standard Dachshunds with X-linked hypohidrotic ectodermal dysplasia. G3 2019 vol. 9(1):95-104;