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Dilated Cardiomyopathy (Schnauzer Type)

Dilated Cardiomyopathy (DCM) (Schnauzer Type) is an inherited cardiac disorder in Schnauzers, characterized by progressive heart muscle weakness leading to severe cardiac complications and often early death.

Affected Genes: RBM20

Inheritance: Autosomal Recessive

Variant(canFam6):
chr28:22298958-22298979

Breed: Giant Schnauzer
Standard Schnauzer

Variant(canFam6):
chr28:22298958-22298979 22 bp deletion

References:
Gilliam D (2016). Molecular Genetic Studies of Canine Inherited Diseases Including SAMS, Neuronal Ceroid Lipofuscinosis and Dilated Cardiomyopathy. (Ph.D. Dissertation). University of Missouri, Columbia, Missouri. Retrieved from https://mospace.umsystem.edu/xmlui/bitstream/handle/10355/56525/research.pdf?sequence=2&isAllowed=y

Harmon MW, Leach SB, Lamb KE. Dilated Cardiomyopathy in Standard Schnauzers: Retrospective Study of 15 Cases. J Am Anim Hosp Assoc. 2017 53(1):38-44.