Cystinuria (Miniature Pinscher Type)
Affected Genes: SLC7A9
Inheritance: Autosomal Dominant
Variant(canFam6):
chr1:118609283: G>A
Breed: Carlin Pinscher
Miniature Pinscher
General Information: Cystinuria (Miniature Pinscher Type) is an inherited kidney disorder in dogs, leading to the formation of urinary stones that can obstruct the urinary tract and cause symptoms like straining to urinate and frequent urination, posing a risk of urinary tract infections and kidney failure if untreated.
How to Read Your Dog's Test Results for this Genetic Variant:
Two Variants Detected: Dog Likely Affected
One Variant Detected: Dog Unlikely Affected
No Variants Detected: No Effect
Gene / Testing Information: Genetic testing of the SLC7A9 gene reveals carriers of cystinuria (Miniature Pinscher Type), inherited in an Autosomal Dominant pattern, where inheriting one mutated gene from a parent is sufficient for disease development. Dogs with the genetic mutation may exhibit mild symptoms or appear healthy, but each offspring of an affected parent has a 50% chance of inheriting the mutation and developing the disease, with higher risk if both parents are affected. Ensuring reliable genetic testing is crucial for responsible breeding practices to prevent the transmission of this mutation and avoid producing affected pups.
References:
Brons AK, Henthorn PS, Raj K, Fitzgerald CA, Liu J, Sewell AC, Giger U. SLC3A1 and SLC7A9 mutations in autosomal recessive and dominant canine cystinuria: A new classification system. J Vet Intern Med. 2013 27(6):1400-1408.