Learn about Copper Toxicosis in Labrador Retrievers, a genetic liver condition linked to the ABCA12 gene. Discover how AlphaDog DNA’s testing kits empower breeders and owners to protect their dogs’ health.
Have you heard, Copper Toxicosis is a silent, inherited condition affecting many Labrador Retrievers? At AlphaDog DNA, we’re committed to empowering pet owners and breeders with genetic insights to safeguard their dogs’ health. In this blog, we’ll explore the science behind Copper Toxicosis, its genetic causes, and how proactive testing can help manage this condition effectively.
What is Copper Toxicosis?
Copper Toxicosis is a genetic liver disorder where excessive copper accumulates in the liver, leading to oxidative damage, inflammation, and eventually liver failure. Labrador Retrievers are particularly susceptible due to a mutation in the ABCA12 gene, which disrupts copper metabolism. Without intervention, symptoms like lethargy, vomiting, and jaundice can emerge, often in adulthood.
Research shows this condition is autosomal recessive, meaning a dog must inherit two copies of the mutated ABCA12 gene (one from each parent) to develop the disease. Carriers (with one copy) typically remain healthy but can pass the mutation to their offspring. This makes genetic testing critical for responsible breeding and early health management.
Diagnosing Copper Toxicosis
Genetic testing provides an opportunity to identify at-risk dogs before symptoms appear through early detection while offering key insights to long-term management and tailored care through collaboration with your veterinarian. For dogs diagnosed with two copies of the mutation, proactive steps can significantly improve their quality of life under the guidance of your veterinarian. Low-copper diets reduce copper intake through vet-recommended nutrition plans. Bloodwork and liver biopsies help track copper levels and liver function; and supplements such as Zin and Vitamin E can support liver health.
Copper Toxicosis is a manageable condition with the right tools and knowledge. At AlphaDog DNA, we’re dedicated to providing accurate genetic insights that help owners and breeders make informed decisions. Together, we can ensure Labrador Retrievers live healthier, happier lives.
Shop AlphaDog DNA’s Complete Canine DNA Test to for proactive management of your dog's health and wellbeing.
